| Heme Oxygenase in Biology and Medicine 2002 Edition Contributor(s): Abraham, Nader G. (Editor) |
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ISBN: 0306472643 ISBN-13: 9780306472640 Publisher: Springer OUR PRICE: $208.99 Product Type: Hardcover - Other Formats Published: August 2002 Annotation: The recent convergence of research in stem cell biology, leukemic cell genetics, and drug discovery has provided remarkable insight into pathogenesis and treatment of leukemia and lymphoma. These insights have led to the new therapeutic approaches involving the manipulation of molecular and/or biochemical pathways in leukemia cells. Nonetheless, effective treatment and cures for these blood-related diseases remains, in many cases elusive. This symposium is designed to integrate recent knowledge regarding the basic cellular and molecular biology of leukemia and lymphoma with new approaches to diagnosis and therapy. To this end, a translation research (laboratory to bedside) approach will be encouraged throughout the meeting, with discussions covering new mechanisms regulating hematopoietic cell development, recent new data from clinical trails of new molecular therapeutics, and newly emerging directions in diagnosis. The symposium will bring together basic, translational, and clinical investigators in a meeting aimed at developing potential collaborative interaction. The intension is to provide new insights into the molecular targets for the treatment of blood-related cancers |
| Additional Information |
| BISAC Categories: - Medical | Oncology - General - Medical | Hematology - Medical | Biochemistry |
| Dewey: 612.015 |
| LCCN: 2002066907 |
| Physical Information: 1.19" H x 7" W x 10" (2.53 lbs) 515 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Heme oxygenase is rapidly taking its place as the centerpiece of multiple inter- acting metabolic systems. Only 25 years ago heme oxygenase and its metabolic prod- ucts appeared to be merely a simple metabolic system-one substrate, heme; one enzyme, heme oxygenase; and one set of products, iron to be recycled, and bilirubin and carbon monoxide to be disposed. From a group of about 25 people in 1974, as judged by attendance at various Gordon conferences, heme oxygenase has, in the year 2000, attracted working scientists-and clinicians I might add-by the hundreds and has produced referenced publications by the thousands. It is well-deserved attention. Heme oxygenase system is now similar to the metabolic networks surrounding glucose in those complex maps of glycolytic and non-glycolytic metabolic pathways, which we had to memorize as students. The relevance of heme oxygenase to regulatory biology was recognized many years ago, but the work conducted over the past five years has created a new wave of emphasis focusing on genetic manipulation to alter heme oxygenase gene expression, the regulatory actions of heme oxygenase products including carbon monoxide, and the significance of changes in the heme oxygenase system. The physiological and pathological relevance of heme oxygenase in the brain, heart, liver, bone marrow, organ transplant, lung and kidney, opens many areas of investigation in various dis- ciplines. Advances in the pharmacology of bilirubin and its ability as an antioxidant have provided a new avenue in clinical research. |