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Genetic Effects on Environmental Vulnerability to Disease
Contributor(s): Rutter, Michael J. (Editor)
ISBN: 047077780X     ISBN-13: 9780470777800
Publisher: Wiley
OUR PRICE:   $113.00  
Product Type: Hardcover - Other Formats
Published: August 2008
Qty:
Temporarily out of stock - Will ship within 2 to 5 weeks
Additional Information
BISAC Categories:
- Medical | Genetics
- Science | Life Sciences - Genetics & Genomics
- Medical | Epidemiology
Dewey: 616.042
Series: Novartis Foundation Symposium
Physical Information: 0.6" H x 6" W x 9" (1.10 lbs) 232 pages
 
Descriptions, Reviews, Etc.
Publisher Description:
Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens.

This book brings together contributions from experts from multiple disciplines who discuss:

  • How epidemiological cohort studies can better integrate physiological (mechanistic) measures;
  • How best to characterise subjects' vulnerability versus resilience by moving beyond single genetic polymorphisms;
  • How gene hunters can benefit from recruiting samples selected for known exposures;
  • How environmental pathogens can be used as tools for gene hunting;
  • How to deal with potential spurious (statistical) interactions, and
  • How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).