| G Protein-Coupled Receptors: From Structure to Function Contributor(s): |
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ISBN: 1849731837 ISBN-13: 9781849731836 Publisher: Royal Society of Chemistry OUR PRICE: $226.10 Product Type: Hardcover - Other Formats Published: August 2011 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Biochemistry - Non-classifiable |
| Dewey: 572.6 |
| Series: RSC Drug Discovery |
| Physical Information: 1.3" H x 6.3" W x 9.3" (2.00 lbs) 548 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. This book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, focuses on the relationship between the structure and function of these receptors. Divided into three parts, it starts by considering what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design. |