| Development of Self Microemulsifying Drug Delivery System Contributor(s): Patel, Maulik (Author), Patel, Sanjay (Author), Dr Natvarlal (Author) |
|
 |
ISBN: 3844331824 ISBN-13: 9783844331820 Publisher: LAP Lambert Academic Publishing OUR PRICE: $50.27 Product Type: Paperback Published: May 2011 |
| Additional Information |
| BISAC Categories: - Medical | Health Care Delivery |
| Physical Information: 0.25" H x 6" W x 9" (0.36 lbs) 104 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate of the drug. However, these methods have their own limitations. In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drugs. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self-microemulsifying drug delivery systems (SMEDDS). |