Booster Dose Vaccination for Preventing Hepatitis B: A Meta-Analysis Contributor(s): Poorolajal, Jalal (Author) |
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ISBN: 3844395865 ISBN-13: 9783844395860 Publisher: LAP Lambert Academic Publishing OUR PRICE: $50.27 Product Type: Paperback Published: May 2011 |
Additional Information |
BISAC Categories: - Medical | Health Policy |
Physical Information: 0.22" H x 6" W x 9" (0.32 lbs) 92 pages |
Descriptions, Reviews, Etc. |
Publisher Description: Hepatitis B virus (HBV) infection is a major public health problem worldwide and HB vaccine is the most effective measure to prevent HB virus infection. An initial anti-HBs threshold value of 10 mIU/ml or greater is considered generally protective. However, the protective antibodies induced by HB vaccine wane gradually over time and may reach very low or even undetectable level. Immunologic studies indicated that HB vaccine induces immunologic memory and memory B cells can generate a rapid and vigorous anamnestic anti-HBs response upon re-exposure to HBsAg. Accordingly, long-term protection after vaccination and the possible need for booster dose of vaccine has remained controversial. To answer this question, we used two different approaches to determine the duration of protection provided by HB vaccine. Four different studies will be presented: a) Seroprotection of HB vaccine and need for booster dose: A meta-analysis b) Long-term protection provided by HB vaccine and need for booster dose: A meta-analysis c) Capture-recapture method for assessing publication bias. d) MetaPlot: A novel Stata graph for assessing heterogeneity at a glance |