Advances in Bioactivation Research 2009 Edition Contributor(s): Elfarra, Adnan (Editor) |
|
ISBN: 0387772995 ISBN-13: 9780387772998 Publisher: Springer OUR PRICE: $208.99 Product Type: Hardcover - Other Formats Published: September 2008 Annotation: This volume will provide researchers with recent information on bioactivation reactions of drugs and toxicants and will provide examples of how molecular and genomic biology, proteomics, mass spectrometry, and computational modeling are used in bioactivation research. In other sections of this volume, focus will be on recent applications of bioactivation research in pharmacology, toxicology, and environmental health sciences. In these sections, the contributors will demonstrate the integration of bioactivation research in several research areas, including new drug design, drug development, mechanisms of cell death, toxicity and carcinogenicity, metabolite-specific biomarkers of exposure and effect, and extrapolations of results from animal models to humans. |
Additional Information |
BISAC Categories: - Medical | Family & General Practice - Medical | Pharmacology - Medical | Immunology |
Dewey: 610.284 |
LCCN: 2008934609 |
Series: Biotechnology: Pharmaceutical Aspects |
Physical Information: 1.1" H x 7" W x 10" (2.30 lbs) 503 pages |
Descriptions, Reviews, Etc. |
Publisher Description: I have always been interested in chemistry and biology. My undergraduate, graduate, and postdoctoral trainings in pharmacy, medicinal chemistry and pharmacology, respectively, have strengthened this interest and led me to realize that significant advances in medicine have frequently been realized because of research at the chem- try-biology interface. I am hoping that this comprehensive volume on recent advances in bioactivation research will stimulate pharmacologists, medicinal chemists, phar- ceutical scientists, and graduate students in these fields and related areas to consider and use bioactivation research when they explore and chart new frontiers in drug design and drug development and when they consider ways to reduce the side effects of existing drugs by making prodrugs. As for the toxicologists and environmental health scientists, I hope this volume will help them generate the knowledge needed to understand better mechanisms of toxicity to improve human risk assessments and intervention methods after occupational or environmental exposure to various hazardous chemicals. Adnan A. Elfarra, Ph. D. vii Part I General Concepts and Basic Mechanisms 1 Metabolic Concerns in Drug Design Jeffrey P. Jones Department of Chemistry, Washington State University, Pullman, WA 99164, USA e-mail: jpj@wsu. edu Keywords: Cytochrome P450 Aldehyde Oxidase Drug-Drug Interactions Mechanism-based Virtual Screening ADMET Regioselectivity 1. 1. Introduction Due to recent technological innovations, such as genomics, combinatorial chemistry, and high-throughput screening, the identification of disease targets and of compounds that are active against these targets (''leads'') can now be carried out efficiently. |