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Solid-Phase Organic Synthesis
Contributor(s): Burgess, Kevin (Author)
ISBN: 0471318256     ISBN-13: 9780471318255
Publisher: Wiley-Interscience
OUR PRICE:   $191.85  
Product Type: Hardcover - Other Formats
Published: November 1999
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Annotation: Solid-Phase Organic Synthesis Edited by Kevin Burgess, Texas A & M University Efficient, high-throughput chemistry is now the focus of many research laboratories. Solid-phase organic syntheses are central to many of these combinatorial and parallel screening methodologies. Consequently, they have been a major scientific theme of the 1990s and promise to remain prominent for the first part of the new millennium. Indeed, a bewildering number of papers have entered the literature on this topic; some report minor modifications enabling transformation of solution-phase methods to a solid support, while others report major innovations. Solid-Phase Organic Synthesis collects, highlights, and critiques some of the key developments in the field. Leading practitioners explain different perspectives on diverse aspects of the area. Specific topics covered include:
  • Syntheses of guanidines
  • Palladium-catalyzed C-C bond forming reactions
  • SnAr reactions for the formation of heterocycles
  • Sequence-specific arylalkyne oligomers
  • Resin-supported capture agents and other reagents
  • Synthesis on pins
  • Monitoring of supported reactions using IR
  • Solid-phase syntheses of natural product derivatives
Of related interest ... Combinatorial Chemistry and Molecular Diversity in Drug Discovery Eric M. Gordon and James F. Kerwin 1998 (0-471-15518-7) 544 pp. Combinatorial Chemistry Synthesis and Application Stephen R. Wilson and Anthony W. Czarnik 1997 (0-471-12687-X) 288 pp.
Additional Information
BISAC Categories:
- Science | Chemistry - Organic
- Science | Chemistry - Physical & Theoretical
Dewey: 547.2
LCCN: 99030796
Physical Information: 1.03" H x 6.33" W x 9.31" (1.31 lbs) 296 pages
 
Descriptions, Reviews, Etc.
Publisher Description:
Die Festphasensynthese spielt eine Schlüsselrolle in der kombinatorischen Chemie, einer neuen Methode der Wirkstofforschung zur raschen, weitgehend automatisierten Synthese, Testung und Archivierung chemischer Verbindungen. Dieses in sich geschlossene Werk beschreibt die wichtigsten Entwicklungen auf diesem Gebiet innerhalb der vergangenen drei Jahre, unter anderem die Festphasensynthese von Naturstoffderivaten und die Palladium-katalysierte C-C-Bindungsknüpfung. (01/00)