| A Perinatal Strategy for Preventing Adult Disease: The Role of Long-Chain Polyunsaturated Fatty Acids 2002 Edition Contributor(s): Das, Undurti N. (Author) |
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ISBN: 1402070705 ISBN-13: 9781402070709 Publisher: Springer OUR PRICE: $104.49 Product Type: Hardcover - Other Formats Published: May 2002 Annotation: This book proposes that fetal growth retardation and low-grade systemic inflammation can be prevented by perinatal supplementation of long-chain polyunsaturated fatty acids (LCPUFAs). Evidence for this hypothesis is presented and discussed in detail, along with possible mechanisms by which these substances produce beneficial actions. Finally, it is suggested that provision of adequate amounts of LCPUFAs during the perinatal period prevents insulin resistance, obesity, type 2 diabetes mellitus, hypertension, CHD, and Alzheimer's disease in the adult. Means of testing the hypothesis are also presented. Thus, the book suggests a simple and novel method of preventing diseases that are increasing in incidence in both the developed and developing worlds. |
| Additional Information |
| BISAC Categories: - Medical | Research - Medical | Perinatology & Neonatology - Medical | Cardiology |
| Dewey: 618.32 |
| LCCN: 2002141584 |
| Physical Information: 0.69" H x 7.06" W x 9" (1.09 lbs) 192 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Obesity, type 2 diabetes mellitus, hypertension, and coronary heart disease are serious diseases affecting asignificantnumberofadults across the globe. Insulin resistance, low-grade systemic inflammation, low-birth weight, maternalproteinmalnutrition, neonatalhighcarbohydratediet, and high fat diet are associated with these diseases. On the other hand, adequatelybreast-fedsubjects are substantially at lowerrisk. Ifso, whatis the linkbetweenthese variousfactors?Onepossibilityisthat humanbreast milk containsfactorsthatconferresistancetothese modemdiseases.Here I present arguments that long-chain polyunsaturated fatty acids (LCPUFAs) presentinthebreastmilkcouldberesponsibleforthisbeneficialaction. Though the entire class of LCPUFAs provided dunng perinatal periodislikelytohavearole inthepreventionofadultdiseases, itshouldbe understoodthateachofthese LCPUFAsexhibitauniqueand insome cases opposing bioactive properties.It is important to note that there is a close interaction between (0-6 and (0-3 fatty acids. Human breast rmlk contains almost twice (0.78 vs 0.43 %w/w)the amountof(0-6LCPUFAs (gamma- linolenic acid, dihomo-gamma-linolenic acid and arachidonic acid) comparedto (0-3LCPUFAs(eicosapentaenoicacid, docosapentaenoicacid, and docosahexaenoic acid). Obviously, the best would be to mimic the composition/concentrations in which these fatty acids are present in the breastmilk. The conceptthat LCPUFAs given duringpennatalperiod(and inadultlife)isbeneficialinpreventingadultdiseasescertainlyneedsfurther exploration.Iamconfidentthat someofthe enterprisingreaderswill delve intothepossibilitiessuggestedafterreadingthisbook. UndurtiN.Das, M.D., FAMS. To MyWifeLakshmi and Mytwoeyes DaughterArundhatiandSonAditya Chapter #1 Introduction Fetal/Perinatalimprintingonlaterlife It isbelievedthat stimuliormsults during criticalorsensitiveperiods inearlylifecanhave lifetimeconsequences.Thisconceptiswellestablished in developmental biology and has been termed "programming". The evidence for programming confirmed the critical period for imprinting in animals, more so in birds'. Programming stimuli may be generated endogenously, such as hormonal signals', or they may be environmental. |