| B3 Adrenoreceptor Contributor(s): Strosberg, A. Donny (Editor) |
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ISBN: 1420023209 ISBN-13: 9781420023206 Publisher: CRC Press OUR PRICE: $161.45 Product Type: Loose Leaf Published: July 2000 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Cell Biology |
| Physical Information: 192 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Since the first pharmacological description of an 'atypical' -adrenoreceptor and the cloning of the 3AR gene, research interest in this receptor has grown considerably and many advances have been made in describing various properties of the 3AR and its ligands. Thanks to the lipolytic activity of 3AR ligands, several of these compounds have now entered clinical trials. Moreover, genotyping for the presence of a polymorphism in the 3AR gene, possibly associated with increased risk of developing diabetes and/or obesity has become one of the possible targets for pharmacogenomic approaches to treat these growing health problems. The 3-adrenoreceptor covers all the latest developments in the field. It begins with a general overview on the structure, function and expression of the 3AR before discussing regulation of the receptor and the consequences of 3AR gene knockout. A detailed description of the receptor's pharmacology and functional role in humans is also given, followed by an account of it's lesser-known vasodilatory role. Throughout, the 3AR is placed in context by reference to 1AR and 2AR homologues as well as the more recently described, still putative, fourth AR Suitable for researchers from industry and academia, this timely book presents a clear and complete description of the 3AR, with contributions from many of those involved in 3AR research from the beginning. |