| Advances in Host-Directed Therapies Against Tuberculosis 2021 Edition Contributor(s): Karakousis, Petros C. (Editor), Hafner, Richard (Editor), Gennaro, Maria Laura (Editor) |
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ISBN: 3030569047 ISBN-13: 9783030569044 Publisher: Springer OUR PRICE: $208.99 Product Type: Hardcover Published: December 2020 |
| Additional Information |
| BISAC Categories: - Medical | Immunology - Medical | Infectious Diseases - Medical | Pharmacology |
| Physical Information: 0.81" H x 6.14" W x 9.21" (1.46 lbs) 332 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: This book discusses specific immune cell regulatory pathway(s), immune cell types, or other mechanisms involved in host responses to tuberculosis that can be potentially targeted for host-directed therapy (HDT). The pathways/mechanisms investigated are either protective - thus calling for pathway/factor enhancing drugs - or maladaptive - thus calling for pathway/factor inhibitory drugs. Discovery and development (pre-clinical and clinical) of candidate HDT agents will also be elucidated, as well as approaches for HDT of other diseases. The benefit to the reader will derive from learning about the biology of multiple host pathways involved in health and disease, how these pathways are disrupted or dysregulated during tuberculosis, and which druggable targets exist in these pathways. This book provides the reader with a roadmap of current and future directions of HDT against tuberculosis. Since the host pathways/factors involved in protective or maladaptive responses to tuberculosis are not disease-specific, information learned from the context of tuberculosis likely will be relevant to other infectious and non-infectious diseases. |