| Oncogenes in B-Cell Neoplasia: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, Usa, March 5-7, 1984 Softcover Repri Edition Contributor(s): Potter, M. (Editor), Melchers, F. (Editor), Weigert, M. (Editor) |
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ISBN: 364269862X ISBN-13: 9783642698620 Publisher: Springer OUR PRICE: $104.49 Product Type: Paperback - Other Formats Published: December 2011 |
| Additional Information |
| BISAC Categories: - Medical | Microbiology - Medical | Infectious Diseases - Medical | Oncology - General |
| Dewey: 576 |
| Series: Current Topics in Microbiology and Immmunology |
| Physical Information: 0.6" H x 6.69" W x 9.61" (1.02 lbs) 268 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Michael Potter, Fritz Melchers, Martin Weigert The second workshop on Mechanisms of B Cell Neoplasia was held in Bethesda, Maryland in Wilson Hall at the National Institutes of Health on March 5, 6, and 7, 1984. It followed a workshop on the same topic that was held at the Basel Institute for Immunology, March 15-17, 1983. That first meeting attempted to bring together cell biologists, experimental pathologists and molecular geneti- cists interested in B cells, to discuss pathogenetic processes in the development and maintenance of the neoplastic state. The impetus for this discussion emanated from two important developments: first, the discovery of the viral promoter insertion mechanism for acti- vating the myc oncogene in bursal lymphomatosis by Hayward, Neil, and Astrin;-second, the findings that the non-random chromosomal trans locations involving the immunoglobulin gene chromosomes occur- red in very high frequencies in murine plasmacytomas and human Burkitt's lymphomas. During the planning stages of that meeting Shen-Ong et al. discovered that non-random translocations activated the myc oncogene. Promoter insertions and non-random trans locations were-rwo mechanisms that caused transcription of the myc oncogene messages in three different kinds of well defined experimental and clinical B cell tumors. Unregulated myc gene transcription provided the first evidence of a specific bioChemical lesion in B cell neo- plasia. |