| 8-oksoguanin i produkty ego okisleniya Contributor(s): Smirnova Violetta Sergeevna (Author), Gudkov Sergey Vladimirovich (Author), Bruskov Vadim Ivanovich (Author) |
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ISBN: 3846526355 ISBN-13: 9783846526354 Publisher: LAP Lambert Academic Publishing OUR PRICE: $60.53 Product Type: Paperback Language: Russian Published: October 2011 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Biochemistry |
| Physical Information: 0.37" H x 6" W x 9" (0.54 lbs) 160 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Aktivnye formy kisloroda (AFK) obrazuyutsya v protsesse normal'nogo aerobnogo kletochnogo metabolizma i v rezul'tate vneshnikh vozdeystviy faktorov okruzhayushchey sredy na organizm. AFK chrezvychayno reaktsionnosposobny i mogut legko vstupat' v okislitel'no-vosstanovitel'nye reaktsii s lipidami, belkami, uglevodami i nukleinovymi kislotami. Eto vyzyvaet narusheniya metabolizma i strukturnoy organizatsii kletki. Naibolee chuvstvitel'noy mishen'yu pri deystvii AFK na DNK yavlyaetsya guanin, a produktom ego okislitel'nogo povrezhdeniya - 8-oksoguanin (8-OG). 8-OG v nastoyashchee vremya schitaetsya odnim iz osnovnykh biomarkerov okislitel'nogo povrezhdeniya DNK. Ustanovlena svyaz' mezhdu obrazovaniem 8-OG i takimi protsessami kak mutagenez, kantserogenez, starenie i patogenezom bolezney pozhilogo vozrasta. Dannaya kniga posvyashchena issledovaniyu molekulyarnykh mekhanizmov, privodyashchikh k generatsii AFK, obrazovaniyu 8-oksoguanina i drugikh povrezhdeniy osnovaniy v DNK pod deystviem takikh faktorov sredy, kak teplo, gamma-izluchenie i iony uranila. |