| Autoimmunity 2001 Edition Contributor(s): Górski, Andrzej (Editor), Krotkiewski, Hubert (Editor), Zimecki, Michal (Editor) |
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ISBN: 9401038775 ISBN-13: 9789401038775 Publisher: Springer OUR PRICE: $161.49 Product Type: Paperback - Other Formats Published: October 2012 |
| Additional Information |
| BISAC Categories: - Medical | Endocrinology & Metabolism - Medical | Immunology - Medical | Internal Medicine |
| Dewey: 616.978 |
| Physical Information: 0.47" H x 6.14" W x 9.21" (0.70 lbs) 207 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The immune system has evolved mechanisms enabli ng it to discriminate between self and non-self constituents. A normally functioning organism is naturally unresponsive to self antigens originating from clonal deletion, aner- gy, or an active suppression of self-reactive T cells. The wide spectrum of autoimmune responses may be divided into systemic and organ-specific dis- eases and encompasses the actions of autoantibodies, autoantigeu-autoanti- body complexes, and sensitized T lymphocytes. The aim of this book is to review the current understandin g, concepts and hypotheses regarding the pathogenesis and therapeutic approaches in autoim- mune disorders. The first six articles are generally concerned with the mech- anisms operating in autoimmune phenomena, whereas the subsequent reviews discuss particular phenomena in representative autoimmune dis- eases. The introductory article underlines the significance of the interactions between antigen-specific T cells and other elements ot the immune system and proposes that not suppression, but rather activation of the immune sys- tem, leading to a redirection of the immune response, would be therapeuti- cally beneficial. The next articles present the importance of costim ulatory signals in determining various types of immune responses, including autoim- munity, and the role of regulatory T cells. Further, an interesting phenome- non of epitope spreading as a mechanism for the progression of autoimmune diseases is presented. |