Compendium of in Vivo Monitoring in Real-Time Molecular Neuroscience - Volume 2: Microdialysis and Sensing of Neural Tissues Contributor(s): Wilson, George S. (Editor), Michael, Adrian C. (Editor) |
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ISBN: 9813220538 ISBN-13: 9789813220539 Publisher: World Scientific Publishing Company OUR PRICE: $169.10 Product Type: Hardcover - Other Formats Published: August 2017 |
Additional Information |
BISAC Categories: - Science | Life Sciences - Neuroscience - Science | Chemistry - Analytic - Technology & Engineering | Biomedical |
Dewey: 612.823 |
Physical Information: 0.9" H x 6.4" W x 9.9" (2.10 lbs) 424 pages |
Descriptions, Reviews, Etc. |
Publisher Description: Volume 1 of this series focused mainly on small molecules which are intrinsically electroactive. Volume 2 continues to provide current approaches to real time measurements of essential species in the central nervous system. It describes microdialysis, a sampling technique, which facilitates the removal of small volumes of solution containing the analyte(s) of interest which can be subsequently separated by chromatography and analyzed by a range of techniques. These include electrochemistry, UV-Vis spectroscopy, fluorescence and mass spectroscopy. This approach affords the opportunity to measure a range of targets in real-time thus providing access to pharmacokinetic/pharmacodynamics measurements affording the possibility of measuring the disappearance of a drug after administration and the subsequent appearance of metabolites. Microdialysis further affords the ability to sample peptides and proteins of neurobiological interest. Consistent with the goals of Volume 1, Volume 2 seeks to provide for scientists in the field of neurobiology a base of bioanalytical techniques that may not be familiar to them. Specific examples are provided and the fundamental basis of the technique is also covered. |