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This trainer's guide was borne out of indicative results of needs assessments of medical trainers who are subject specialists but have minimal skills in executing curricula into classroom teaching and learning. The learning material in this guide is designed and developed using principles of problem-based learning. It offers practical suggestions on lesson planning, classroom and laboratory activities and presentation templates applicable to competency training. The development of numerous professional and positive life skills can be attributed to problem-based learning. These skills include; communication, professional values and ethics, teamwork, reflective practice, self-regulation, self-responsibility, self-drive, independent and life-long learning. This guide has been designed to incorporate teaching and learning methods that develop these skills.