| CYP2D6 genetic polymorphisms and tramadol's action Contributor(s): Gan, Siew Hua (Author) |
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ISBN: 3639241150 ISBN-13: 9783639241150 Publisher: VDM Verlag OUR PRICE: $81.05 Product Type: Paperback Published: March 2010 |
| Additional Information |
| BISAC Categories: - Medical | Health Policy |
| Physical Information: 0.66" H x 6" W x 9" (0.95 lbs) 292 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Despite recent advances in anaesthesia, postoperative analgesia remains a problem. This is compounded by the fact that fear of drug dependence exists with the use of conventional opioid analgesics. Therefore, there are needs for using new drugs such as tramadol hydrochloride. Due to its additional action on the monoaminergic system, this drug is also coined as an "atypical opioid". Tramadol is metabolised by the CYP2D6 enzyme which is one of the most polymorphic enzyme systems. Due to the wide interethnic variabilities in metabolising tramadol, a pharmacogenetic-pharmacokinetic study is timely and may be a useful tool for establishing optimum dosage regimens of tramadol in future. This book describes the correlation of the CYP2D6 gene with tramadol's pharmacokinetics and pharmacodynamics. |